Integrating Polygenic Scores with Clinical, Lifestyle, and Social Risk Factors to Improve Heart Failure Risk Prediction.

Abstract excerpt

Heart failure (HF) is highly prevalent, high-burden disorder with its prevalence expected to increase. Early detection of HF can reduce morbidity and mortality; therefore, novel early detection methods are needed. Polygenic scores (PGS) can combine common variants across the genome and provide phenotype-specific risk scores. However, there are also many well-known, non-genomic risk factors of HF, in the clinical,...

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