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Article

Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments

12 Apr 2021

Abstract excerpt

Background: Polygenic risk scores (PRS) for coronary heart disease (CHD) may contribute to assess the overall risk of CHD. We evaluated how PRS may influence CHD risk when the distribution of age-at-onset, sex, and family health history differ significantly. Methods: Our study included 3 family-based ascertainments: LLFS (Long Life Family Study, N Individuals =4572), which represents a low CHD risk, and Family...

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PMID: 33844929
DOI: 10.1161/circgen.120.003201

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