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Sperm flagellar 2 (SPEF2) is essential for sperm flagellar assembly in humans

5 Nov 2021

Abstract excerpt

Spermiogenesis is a complex and tightly regulated process, consisting of acrosomal biogenesis, condensation of chromatin, flagellar assembly, and disposal of extra cytoplasm. Previous studies have reported that sperm flagellar 2 (SPEF2) deficiency causes severe asthenoteratozoospermia owing to spermiogenesis failure, but the underlying molecular mechanism in humans remains unclear. Here, we performed proteomic...

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PMID: 34755699
DOI: 10.4103/aja202154

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