Article
Lethal phenotype of mice carrying a Sept11 null mutation.
Biological chemistry - 1 Aug 2011
Röseler Sabrina, Sandrock Kirstin, Bartsch Ingrid, Busse Anja, Omran Heymut, Loges Niki T, Zieger Barbara
Abstract excerpt
Septins are cytoskeletal GTP-binding proteins involved in processes characterized by active membrane movement, such as cytokinesis, vesicle trafficking and exocytosis. Most septins are expressed ubiquitously, however, some septins accumulate in particular tissues. The ubiquitous SEPT11 also shows high expression levels in the central nervous system and in platelets. Here, SEPT11 is involved in vesicle trafficking...
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