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Article

Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants.

The Journal of allergy and clinical immunology - 1 Dec 2025

Shook Molly S, Lu Xiaoming, Chen Xiaoting, Edsall Lee E, Granitto Marissa, Virolainen Samuel J, Forney Carmy, Donmez Omer A, Parameswaran Sreeja, Fadden Catherine, Dexheimer Phillip J, Jenkins Seth, Grashel Brittany, Kaufman Kenneth M, Hershey Gurjit Khurana, Martin Lisa J, Satish Latha, Weirauch Matthew T, Kottyan Leah C

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is an inflammatory, pruritic disease of the skin with a complex etiology involving environmental and genetic factors. Numerous genetic risk loci for AD have been nominated through genome-wide association studies, with most associated variants residing in noncoding regions. Further work is needed to understand how genetic variation contributes to disease-related alterations to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40846081
DOI: 10.1016/j.jaci.2025.07.032
PMCID: PMC12863760

Genes

FLG
KIF3A

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