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Article

Transcriptome-wide analyses delineate the genetic architecture of expression variation in atopic dermatitis.

HGG advances - 10 Apr 2025

Antonatos Charalabos, Mitsoudi Dimitra, Pontikas Alexandros, Akritidis Adam, Xiropotamos Panagiotis, Georgakilas Georgios K, Georgiou Sophia, Tsiogka Aikaterini, Gregoriou Stamatis, Grafanaki Katerina, Vasilopoulos Yiannis

Abstract excerpt

Genome-wide association studies (GWASs) for atopic dermatitis (AD) have uncovered 81 risk loci in European participants; however, translating these findings into functional and therapeutic insights remains challenging. We conducted a transcriptome-wide association study (TWAS) in AD leveraging cis-eQTL data from sun exposed (n = 517), non-sun exposed skin (n = 602) and whole blood (n = 670) tissues and the latest...

Read the complete abstract on PubMed

Topics

Dermatitis, Atopic
Humans
Genome-Wide Association Study
Transcriptome
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Quantitative Trait Loci

Multifactorial Inheritance

Gene Regulatory Networks

Gene Expression Regulation

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40017037
DOI: 10.1016/j.xhgg.2025.100422
PMCID: PMC11937661

Genes

ACER3
AFF4
AQP7
FOSL1
HSPA4
LCE3D
LCE3E
RORC
TAPBPL

Provenance

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