Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen.

Journal of environmental science and health. Part C, Toxicology and carcinogenesis - 1 Jan 2025

Guo Xiaoqing, Seo Ji-Eun, Miranda-Colon Jaime, Xu Hannah, Revollo Javier, Heflich Robert H

Abstract excerpt

Accurately evaluating chemical risk may benefit from the development of human-relevant models capable of capturing the effects of treatments that closely mimic real-world environmental and pharmaceutical exposures. Building on our previous work (Seo et al. Arch Toxicol 98:1919-1935),1 where cytotoxicity compromised mutation detection following short-term treatments, this study investigated mutation accumulation...

Read the complete abstract on PubMed

Topics

Humans
DNA Damage
Mutation
Dimethylnitrosamine
Mutagens
Carcinogens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Micronucleus Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 40844802
DOI: 10.1080/26896583.2025.2548146
PMCID: PMC12401553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen.PMID 40844802Read ↗

Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing.Semantic proximity Read ↗

Quantitative genotoxicity assessment of N-nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination.Semantic proximity Read ↗

Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro.Semantic proximity Read ↗

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT).Semantic proximity Read ↗

High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?Semantic proximity Read ↗

N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations.Semantic proximity Read ↗

Adopting Duplex Sequencing™ Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed RatsSemantic proximity Read ↗

Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.Semantic proximity Read ↗

Genotoxicity Assessment of Nanomaterials: Recommendations on Best Practices, Assays, and Methods.Semantic proximity Read ↗

Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.Semantic proximity Read ↗

Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis.Semantic proximity Read ↗

Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.