Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smad2 Is Essential for Maintenance of the Human and Mouse Primed Pluripotent Stem Cell State

6 May 2013

Abstract excerpt

Human embryonic stem cells and mouse epiblast stem cells represent a primed pluripotent stem cell state that requires TGF-β/activin signaling. TGF-β and/or activin are commonly thought to regulate transcription through both Smad2 and Smad3. However, the different contributions of these two Smads to primed pluripotency and the downstream events that they may regulate remain poorly understood. We addressed the...

Source

Identifiers

PMID: 23649632
DOI: 10.1074/jbc.m112.446591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smad2 Is Essential for Maintenance of the Human and Mouse Primed Pluripotent Stem Cell StatePMID 23649632Read ↗

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cellsSemantic proximity Read ↗

Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cellsSemantic proximity Read ↗

Activin/Nodal signalling maintains pluripotency by controlling Nanog expressionSemantic proximity Read ↗

Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signalingSemantic proximity Read ↗

Concise Review: Pursuing Self-Renewal and Pluripotency with the Stem Cell Factor NanogSemantic proximity Read ↗

JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming processSemantic proximity Read ↗

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinctionSemantic proximity Read ↗

Role of Oct4 in maintaining and regaining stem cell pluripotencySemantic proximity Read ↗

Deciphering the mRNA-lncRNA-miRNA interaction landscape in human pluripotencySemantic proximity Read ↗

TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cellsSemantic proximity Read ↗

Deconstructing the pluripotency gene regulatory network.Semantic proximity Read ↗

Male fetal germ cell differentiation involves complex repression of the regulatory network controlling pluripotencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.