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Male fetal germ cell differentiation involves complex repression of the regulatory network controlling pluripotency

15 Apr 2010

Abstract excerpt

Mammalian germ cells are derived from the pluripotent epiblast and share features with pluripotent stem cells, including the expression of key genes that regulate developmental potency. The core genes Oct4, Sox2, and Nanog that regulate pluripotency in stem cells also perform important roles in regulating germ cell development and potentially in occurrence of germ line tumors in humans. Despite this, our...

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PMID: 20395456
DOI: 10.1096/fj.09-151555

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