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Article

RIG-I and IL-6 are negative-feedback regulators of STING induced by double-stranded DNA

14 Aug 2017

Abstract excerpt

The stimulator of interferon genes (STING) protein has emerged as a critical signal transduction molecule in the innate immune response. Sustained activation of the STING signaling induced by cytosolic DNA has been considered to be the cause of a variety of autoimmune diseases characterized by uncontrolled inflammation. Therefore, it is important to understand the molecular basis of the regulation of STING...

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PMID: 28806404
DOI: 10.1371/journal.pone.0182961

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