Article
TAC1b mutation in Candida auris decreases manogepix susceptibility owing to increased CDR1 expression
18 Dec 2024
Abstract excerpt
ABSTRACT Candida auris is an emerging pathogenic fungus that is highly resistant to existing antifungal drugs. Manogepix is a novel antifungal agent that exerts antifungal activity by inhibiting glycosylphosphatidylinositol anchor biosynthesis. Although the mechanisms of resistance of Candida species to manogepix have been reported previously, those of C. auris are yet to be studied. To investigate the resistance...
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