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Article

Regulation of neuronal excitability in Drosophila by constitutively active CaMKII.

Journal of neurobiology - 1 Jul 2002

Park Demian, Coleman Melissa J, Hodge James J L, Budnik Vivian, Griffith Leslie C

Abstract excerpt

The ability of calcium/calmodulin-dependent protein kinase II (CaMKII) to become calcium independent after autophosphorylation makes this enzyme a temporal marker of neuronal activity. Here we show that the calcium-independent form of CaMKII has unique effects on larval viability, locomotion, and neuronal excitability in Drosophila. Expression of constitutively active T287D, but not calcium-dependent T287A,...

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Identifiers

PMID: 12115891
DOI: 10.1002/neu.10066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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