Article
Associations between epilepsy-related polygenic risk and brain morphology in childhood.
Brain : a journal of neurology - 7 Feb 2026
Ngo Alexander, Liu Lang, Larivière Sara, Kebets Valeria, Fett Serena, Weber Clara F, Royer Jessica, Yu Eric, Rodríguez-Cruces Raúl, Zhang Zhiqiang, Ooi Leon Qi Rong, Yeo B T Thomas, Frauscher Birgit, Paquola Casey, Caligiuri Maria Eugenia, Gambardella Antonio, Concha Luis, Keller Simon S, Cendes Fernando, Yasuda Clarissa L, Bonilha Leonardo, Gleichgerrcht Ezequiel, Focke Niels K N, Kotikalapudi Raviteja, O'Brien Terence J, Sinclair Benjamin, Vivash Lucy, Desmond Patricia M, Lui Elaine, Vaudano Anna Elisabetta, Meletti Stefano, Kälviäinen Reetta, Soltanian-Zadeh Hamid, Winston Gavin P, Tiwari Vijay K, Kreilkamp Barbara A K, Lenge Matteo, Guerrini Renzo, Hamandi Khalid, Rüber Theodor, Bauer Tobias, Devinsky Orrin, Striano Pasquale, Kaestner Erik, Hatton Sean N, Caciagli Lorenzo, Kirschner Matthias, Duncan John S, Thompson Paul M, McDonald Carrie R, Sisodiya Sanjay M, Bernasconi Neda, Bernasconi Andrea, Gan-Or Ziv, Bernhardt Boris C
Abstract excerpt
Extensive neuroimaging research in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) has identified brain atrophy as a disease phenotype. While it is also related to a complex genetic architecture, the transition from genetic risk factors to brain vulnerabilities remains unclear. Using a population-based approach, we examined the associations between epilepsy-related polygenic risk for HS (PRS-HS) and...
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