Article
Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases.
Science (New York, N.Y.) - 4 Feb 2022
Makowski Carolina, van der Meer Dennis, Dong Weixiu, Wang Hao, Wu Yan, Zou Jingjing, Liu Cin, Rosenthal Sara B, Hagler Donald J, Fan Chun Chieh, Kremen William S, Andreassen Ole A, Jernigan Terry L, Dale Anders M, Zhang Kun, Visscher Peter M, Yang Jian, Chen Chi-Hua
Abstract excerpt
To determine the impact of genetic variants on the brain, we used genetically informed brain atlases in genome-wide association studies of regional cortical surface area and thickness in 39,898 adults and 9136 children. We uncovered 440 genome-wide significant loci in the discovery cohort and 800 from a post hoc combined meta-analysis. Loci in adulthood were largely captured in childhood, showing signatures of...
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