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Article

Clinicopathologic features and therapeutic outcomes in EGFR/ALK-aberrations NSCLC with histologic transformation.

Journal of translational medicine - 23 Dec 2025

Ding Kaibo, Li Xinyue, Li Hui, Qin Jing, Liu Dujiang, Xu Yanjun

Abstract excerpt

BACKGROUND: The aim of this study is to delineate clinicopathologic features, therapeutic outcomes, and tumor microenvironment (TME) remodeling in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor/anaplastic lymphoma kinase (EGFR/ALK) aberrations who experience histologic transformation (HT), with emphasis on post-transformation treatment efficacy. METHODS: This single-center...

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Share to Anaplastic Lymphoma Kinase
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to ErbB Receptors

Share to Lung Neoplasms

Share to Protein Kinase Inhibitors

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Source

Open in PubMed Open full text

Identifiers

PMID: 41430258
DOI: 10.1186/s12967-025-07540-w
PMCID: PMC12836998

Genes

EGFR
ALK
PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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