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Article

Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease.

Journal of neuroinflammation - 9 Aug 2025

Gollihue Jenna L, Aung Khine Zin, Rogers Colin B, Galopin Leopoldine B, Wright Nicholas A, Sompol Pradoldej, Weekman Erica M, Katsumata Yuriko, Morganti Josh M, Norris Christopher M

Abstract excerpt

Hyperhomocysteinemia (HHcy)-inducing diets recapitulate cerebral small vessel disease phenotypes in mice including cerebrovascular pathology/dysfunction, neuroinflammation, synaptic deficits, and cognitive decline. We recently showed that astrocyte signaling through calcineurin(CN)/nuclear factor of activated T cells (NFATs) plays a causative role in these phenotypes. Here, we assessed the impact of astrocytic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40783543
DOI: 10.1186/s12974-025-03523-2
PMCID: PMC12335036

Genes

P2RY12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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