Article
The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina.
Development (Cambridge, England) - 1 Dec 2011
Hirota Shinya, Liu Qian, Lee Hye Shin, Hossain Mohammad G, Lacy-Hulbert Adam, McCarty Joseph H
Abstract excerpt
The mouse retina is vascularized after birth when angiogenic blood vessels grow and sprout along a pre-formed latticework of astrocytes. How astrocyte-derived cues control patterns of blood vessel growth and sprouting, however, remains enigmatic. Here, we have used molecular genetic strategies in mice to demonstrate that αvβ8 integrin expressed in astrocytes is essential for neovascularization of the developing...
Topics
- Animals
- Astrocytes
- DNA Primers
- Fluorescent Antibody Technique
- Genotype
- Immunoblotting
- Integrins
- Mice
- Paracrine Communication
- Retinal Vessels