Article

Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of small cerebral vessel disease

2025-03-17

Abstract excerpt

<title>Abstract</title> <p>Hyperhomocysteinemia (HHcy)-inducing diets recapitulate small cerebral vessel disease phenotypes in mice including cerebrovascular pathology/dysfunction, neuroinflammation, synaptic deficits, and cognitive decline. We recently showed that astrocyte signaling through calcineurin(CN)/nuclear factor of activated T cells (NFATs) plays a causative role in these phenotypes. Here, we assessed...

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Literature Corpus work: 1bab75e4-e4f5-5e01-8ad8-2eb931443de2
DOI: 10.21203/rs.3.rs-6198453/v1

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