Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states.

Acta neuropathologica communications - 19 Dec 2023

Morton Lorena, Arndt Philipp, Garza Alejandra P, Henneicke Solveig, Mattern Hendrik, Gonzalez Marilyn, Dityatev Alexander, Yilmazer-Hanke Deniz, Schreiber Stefanie, Dunay Ildiko R

Abstract excerpt

Vascular risk factors such as chronic hypertension are well-established major modifiable factors for the development of cerebral small vessel disease (cSVD). In the present study, our focus was the investigation of cSVD-related phenotypic changes in microglia in human disease and in the spontaneously hypertensive stroke-prone rat (SHRSP) model of cSVD. Our examination of cortical microglia in human post-mortem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Small Vessel Diseases
Share to Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microglia

Share to Phenotype

Share to Rats, Inbred SHR

Source

Open in PubMed Open full text

Identifiers

PMID: 38115109
DOI: 10.1186/s40478-023-01672-0
PMCID: PMC10729582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states.PMID 38115109Read ↗

Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive statesSemantic proximity Read ↗

Microglia Phenotypes in Aging and Neurodegenerative Diseases.Semantic proximity Read ↗

Transcriptomic characterization of microglia activation in a rat model of ischemic stroke.Semantic proximity Read ↗

Microglia heterogeneity along a spatio–temporal axis: More questions than answersSemantic proximity Read ↗

Microglial immunosurveillance after ischemic stroke: dynamic phenotypes, neurovascular interactions, and therapeutic opportunities.Semantic proximity Read ↗

Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets.Semantic proximity Read ↗

Microglia phenotype diversity.Semantic proximity Read ↗

Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic interventionSemantic proximity Read ↗

PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and NeuroinflammationSemantic proximity Read ↗

Pericytes mediate neurovascular remodeling in chronic arterial hypertensionSemantic proximity Read ↗

Heterogeneity of Microglia Phenotypes: Developmental, Functional and Some Therapeutic ConsiderationsSemantic proximity Read ↗

Microglia as therapeutic target in central nervous system disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.