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Article

Genotyping of selected germline adaptive immune system loci using short-read sequencing data.

Genome research - 2 Sept 2025

Ford Michael K B, Hari Ananth, Yeager Meredith, Mirabello Lisa, Chanock Stephen, Numanagić Ibrahim, Sahinalp S Cenk

Abstract excerpt

As we enter the age of personalized medicine, healthcare is increasingly focused on tailoring diagnoses and treatments based on patients' genetic and environmental circumstances. A critical component of a person's physiological makeup is their immune system, but individual genetic variation in many immune system genes has remained resistant to analysis using classical whole-genome or targeted sequencing...

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PMID: 40764056
DOI: 10.1101/gr.280314.124
PMCID: PMC12401057

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