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Identification of a unique subpopulation of mucosal fibroblasts in colorectal cancer with tumor-restraining characteristics

5 Aug 2025

Abstract excerpt

While tumor-restraining cancer-associated fibroblasts (Tr-CAFs) have been investigated in various cancers, their existence in colorectal cancer remains unexplored. We performed a comprehensive analysis of diverse colorectal cancer datasets, including single-cell RNA-seq/ATAC-seq data from colorectal samples, TCGA RNA-seq, and histological samples. We identified a fibroblast subpopulation uniquely expressing...

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PMID: 40759242
DOI: 10.1016/j.mocell.2025.100263

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