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Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling

29 May 2024

Abstract excerpt

Cancer-associated fibroblasts play a crucial role within the tumor microenvironment. However, a comprehensive characterization of CAF in colorectal cancer (CRC) is still missing. We combined scRNA-seq and spatial proteomics to decipher fibroblast heterogeneity in healthy human colon and CRC at high resolution. Analyzing nearly 23,000 fibroblasts, we identified 11 distinct clusters and verified them by spatial...

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PMID: 38821255
DOI: 10.1016/j.canlet.2024.216985

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