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Article

Association between serum corin in the second trimester and hypertensive disorders of pregnancy: a mendelian randomization study.

Placenta - 1 Sept 2025

Zhang Xueyang, Yu Qing, Liu Junjiang, Feng Pei, Fan Wenxiu, Jin Yibing, Yang Xiangdong, Li Hongmei, Wu Lei, Peng Hao

Abstract excerpt

BACKGROUND: Serum corin has been associated with hypertensive disorders of pregnancy (HDP) in clinical studies but lacks causal evidence. This study aimed to systemically examine the associations of serum corin and its coding gene polymorphisms with HDP, as well as the underlying causality among Chinese pregnant women. METHODS: A nested case-control study comprising 403 cases of HDP and 402 age- and...

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Case-Control Studies
Hypertension, Pregnancy-Induced
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy Trimester, Second

Serine Endopeptidases

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PMID: 40753787
DOI: 10.1016/j.placenta.2025.07.091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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