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Causal pathways in preeclampsia: a Mendelian randomization study in European populations.

Frontiers in endocrinology - 1 Jan 2024

Tan Zilong, Ding Mengdi, Shen Jianwu, Huang Yuxiao, Li Junru, Sun Aochuan, Hong Jing, Yang Yan, He Sheng, Pei Chao, Luo Ran

Abstract excerpt

Purpose: Our study utilizes Mendelian Randomization (MR) to explore the causal relationships between a range of risk factors and preeclampsia, a major contributor to maternal and perinatal morbidity and mortality. Methods: Employing the Inverse Variance Weighting (IVW) approach, we conducted a comprehensive multi-exposure MR study analyzing genetic variants linked to 25 risk factors including metabolic disorders,...

Topics

Humans
Female
Mendelian Randomization Analysis
Pregnancy
Pre-Eclampsia
Risk Factors
White People
Europe
Genetic Predisposition to Disease
Adult
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39286274
DOI: 10.3389/fendo.2024.1453277
PMCID: PMC11402816

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