Article
Causal association of sex hormone-binding globulin on gestational hypertension and pre-eclampsia: a two-sample Mendelian randomization study.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 1 Dec 2024
Wu Zhiwei, Chen Jinzao, Huang Kaijian, Li Yiming, Chen Jianbin, Lin Bin, Lin Chunhua, Pan Guoyan
Abstract excerpt
OBJECTIVES: Pre-eclampsia (PE) and gestational hypertension (GH) are two different categories of hypertensive disorders of pregnancy. Given earlier observational research, the relationship between sex hormone-binding globulin (SHBG) and a higher risk of GH/PE is still up for dispute. Hence, the present investigation aimed to examine the possible link between SHBG and the likelihood of GH/PE. METHODS: As a first...
Topics
- Humans
- Female
- Sex Hormone-Binding Globulin
- Pregnancy
- Mendelian Randomization Analysis
- Pre-Eclampsia
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide