Article
Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study.
Hypertension (Dallas, Tex. : 1979) - 1 May 2023
Hosier Hillary, Lipkind Heather S, Rasheed Humaira, DeWan Andrew T, Rogne Tormod
Abstract excerpt
BACKGROUND: Preeclampsia is a leading cause of maternal morbidity, and dyslipidemia has been associated with preeclampsia in observational studies. We use Mendelian randomization analyses to estimate the association between lipid levels, their pharmacological targets, and the risk of preeclampsia in 4 ancestry groups. METHODS: We extracted uncorrelated (R2<0.001) single-nucleotide polymorphisms strongly...
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