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Article

Construction of Gene Regulatory Networks Based on Spatial Multi-Omics Data and Application in Tumor-Boundary Analysis

13 Jul 2025

Abstract excerpt

BACKGROUND/OBJECTIVES: Cell-cell communication (CCC) is a critical process within the tumor microenvironment, governing regulatory interactions between cancer cells and other cellular subpopulations. Aiming to improve the accuracy and completeness of intercellular gene-regulatory network inference, we constructed a novel spatial-resolved gene-regulatory network framework (spGRN). METHODS: Firstly, the spatial...

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PMID: 40725477
DOI: 10.3390/genes16070821

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