Inferring ligand-receptor cellular networks from bulk and spatial transcriptomic datasets with BulkSignalR

Abstract excerpt

<h4>ABSTRACT</h4> The study of cellular networks mediated by ligand-receptor interactions has attracted much attention recently owing to single-cell omics. However, rich collections of bulk data accompanied with clinical information exists and continue to be generated with no equivalent in single-cell so far. In parallel, spatial transcriptomic (ST) analyses represent a revolutionary tool in biology. A large numb...

Topics

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• Acute Myeloid Leukemia Research
• Bioinformatics and Genomic Networks
• Breast Neoplasms
• Gene Expression Profiling
• Phenotype
• Single-cell and spatial transcriptomics
• Transcriptome

Identifiers and source

Literature Corpus work

60838704-4eef-5c25-ad1b-c62fcd40dfc6

DOI

10.1101/2022.11.17.516911