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Spatial transcriptomics identifies SPARC as a prognostic marker in interstitial lung diseases

28 Jul 2025

Abstract excerpt

Interstitial lung diseases (ILDs) encompass a diverse group of pulmonary disorders, with progressive fibrosis leading to poor prognosis. Here we aimed to identify key molecules involved in progressive fibrosis across various ILDs, using spatial transcriptomics (ST). ST analysis (Visium) was performed on lung cryobiopsy specimens from five patients with various ILDs. Two cases, rich in young fibrotic lesions, as...

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PMID: 40719154
DOI: 10.1002/path.6451

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