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Molecular and Immune Signatures, and Pathological Trajectories of Fatal Covid-19 Lungs Defined by in Situ Spatial Single-Cell Transcriptome Analysis

2023-04-27

Abstract excerpt

The underlying pathological mechanism of coronavirus disease 2019 (COVID-19) remain poorly defined. We examined postmortem COVID-19 lungs by spatial single-cell transcriptome analysis, and revealed altered parenchymal cells, increased innate and adaptive immune cells, and associated differentially expressed genes. Regions with high infection rates have high cell densities (HIHD) with upregulation of ACE2, FURIN, T...

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Literature Corpus work
e83b5788-5d98-5db0-a05f-bef77c443c3a
DOI
10.2139/ssrn.4414848
Open publication

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