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Article

Spatially resolved gene expression profiles of fibrosing interstitial lung diseases

2 Nov 2024

Abstract excerpt

Fibrosing interstitial lung diseases (ILDs) encompass a diverse range of scarring disorders that lead to progressive lung failure. Previous gene expression profiling studies focused on idiopathic pulmonary fibrosis (IPF) and bulk tissue samples. We employed digital spatial profiling to gain new insights into the spatial resolution of gene expression across distinct lung microenvironments (LMEs) in IPF, chronic...

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PMID: 39488596
DOI: 10.1038/s41598-024-77469-5

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