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Article

Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis

17 Nov 2023

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis (transition zones including fibroblastic foci) and dense fibrosis. Defining transcriptional differences between these pathologically heterogeneous regions of the IPF lung is critical to understanding the distribution and extent of fibrotic...

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PMID: 37978501
DOI: 10.1186/s12931-023-02572-6

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