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Article

Predicting T cell receptor functionality against mutant epitopes.

Cell genomics - 11 Sept 2024

Drost Felix, Dorigatti Emilio, Straub Adrian, Hilgendorf Philipp, Wagner Karolin I, Heyer Kersten, López Montes Marta, Bischl Bernd, Busch Dirk H, Schober Kilian, Schubert Benjamin

Abstract excerpt

Cancer cells and pathogens can evade T cell receptors (TCRs) via mutations in immunogenic epitopes. TCR cross-reactivity (i.e., recognition of multiple epitopes with sequence similarities) can counteract such escape but may cause severe side effects in cell-based immunotherapies through targeting self-antigens. To predict the effect of epitope point mutations on T cell functionality, we here present the random...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39151427
DOI: 10.1016/j.xgen.2024.100634
PMCID: PMC11480844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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