The causal link between osteoarthritis and falls: the mediating role of paracetamol

Abstract excerpt

BACKGROUND: Some observational studies have indicated that osteoarthritis (OA) is a fall risk factor. However, the causal relationship between OA and falls remains unclear. METHODS: We conducted a two-step Mendelian randomization (MR) to investigate the causal relationships between OA, paracetamol use, and the risk of falls and to estimate the mediating effect of paracetamol use. Publicly accessible data for hip...

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