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Gut-tropic α4β7+CD8+ T cells contribute to pancreatic β cell destruction in type 1 diabetes

10 Jul 2025

Abstract excerpt

Background T cells are crucial in destroying pancreatic β cells, resulting in insulitis in type 1 diabetes (T1D). However, only 1% to 2% of infiltrating CD8+ T cells are specific for islet autoantigens. The mechanisms driving non-cognate T cells to the islets and their potential pathogenic roles remain unclear. Methods We analyzed the frequency and function of circulating gut-tropic immune cells in 99 patients...

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PMID: 40709181
DOI: 10.3389/fimmu.2025.1623428

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