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Article

PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages.

Atherosclerosis - 1 Apr 2017

Zuniga Mary C, Raghuraman Gayatri, Hitchner Elizabeth, Weyand Cornelia, Robinson William, Zhou Wei

Abstract excerpt

BACKGROUND AND AIMS: Resistin has been associated with atherosclerotic inflammation and cardiovascular complications. We and others have previously shown that PKC-epsilon (PKCε) is involved in resistin-induced smooth muscle cell (VSMC) dysfunction at a high pathological concentration. This study aimed to evaluate the role and potential pathways of resistin at a physiological concentration, in...

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Source

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Identifiers

PMID: 28286252
DOI: 10.1016/j.atherosclerosis.2017.02.021
PMCID: PMC5395299

Genes

TLR4
MIP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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