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NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis

21 Jul 2025

Abstract excerpt

RNA 5-methylcytosine (m 5 C), a prevalent epitranscriptomic modification that critically regulates gene expression and cellular homeostasis. While its roles in solid tumors have been increasingly recognized, the functional landscape of m 5 C in acute myeloid leukemia (AML) remains unexplored. Here, we identified NSUN2, the principal RNA m 5 C methyltransferase, as a key regulator of AML progression. NSUN2 was...

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PMID: 40691844
DOI: 10.1186/s12943-025-02394-8

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