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Article

Vitamin D attenuates PCSK9-driven phenotypic switch of vascular smooth muscle cells and neointimal hyperplasia via SIRT6 activation.

Biochimica et biophysica acta. Molecular basis of disease - 1 Mar 2026

Duddu Sushmitha, Katakia Yash T, Suresh Nivedha, Chakrabarti Rituparna, Majumder Syamantak, Shukla Praphulla Chandra

Abstract excerpt

Pathologically activated vascular smooth muscle cells (VSMCs) upregulate proprotein convertase subtilisin/kexin type 9 (PCSK9), contributing to vascular inflammation and remodeling. Although both PCSK9 and 25-hydroxyvitamin D (25OHD), the active form of Vitamin D, are linked to inflammatory regulation, their interaction in modulating VSMC phenotype remains unclear. Here, we investigated the effect of 25OHD on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41391502
DOI: 10.1016/j.bbadis.2025.168135

Genes

PCSK9
SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Vitamin D attenuates PCSK9-driven phenotypic switch of vascular smooth muscle cells and neointimal hyperplasia via SIRT6 activation.PMID 41391502Read ↗

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