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Article

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension.

Cell death & disease - 5 Oct 2017

Sun Hai-Jian, Ren Xing-Sheng, Xiong Xiao-Qing, Chen Yun-Zhi, Zhao Ming-Xia, Wang Jue-Jin, Zhou Ye-Bo, Han Ying, Chen Qi, Li Yue-Hua, Kang Yu-Ming, Zhu Guo-Qing

Abstract excerpt

Inflammation is involved in pathogenesis of hypertension. NLRP3 inflammasome activation is a powerful mediator of inflammatory response via caspase-1 activation. The present study was designed to determine the roles and mechanisms of NLRP3 inflammasome in phenotypic modulation and proliferation of vascular smooth muscle cells (VSMCs) in hypertension. Experiments were conducted in spontaneously hypertensive rats...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

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Identifiers

PMID: 28981106
DOI: 10.1038/cddis.2017.470
PMCID: PMC5680591

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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