Article
NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2017
Wu Darrell, Ren Pingping, Zheng Yanqiu, Zhang Lin, Xu Gaiping, Xie Wanmu, Lloyd Eric E, Zhang Sui, Zhang Qianzi, Curci John A, Coselli Joseph S, Milewicz Dianna M, Shen Ying H, LeMaire Scott A
Abstract excerpt
OBJECTIVE: Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and dissection (AAD) development. However, the mechanisms underlying SMC contractile dysfunction in sporadic AAD are poorly understood. In this study, we examined the role of the NLRP3 (nucleotide oligomerization domain-like receptor...
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