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MetaGeno: a chromosome-wise multi-task genomic framework for ischaemic stroke risk prediction

1 Jul 2025

Abstract excerpt

Current genome-wide association studies provide valuable insights into the genetic basis of ischaemic stroke (IS) risk. However, polygenic risk scores, the most widely used method for genetic risk prediction, have notable limitations due to their linear nature and inability to capture complex, nonlinear interactions among genetic variants. While deep neural networks offer advantages in modeling these complex...

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PMID: 40676916
DOI: 10.1093/bib/bbaf348

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