Article
Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort.
The Lancet. Digital health - 1 Feb 2022
Steinfeldt Jakob, Buergel Thore, Loock Lukas, Kittner Paul, Ruyoga Greg, Zu Belzen Julius Upmeier, Sasse Simon, Strangalies Henrik, Christmann Lara, Hollmann Noah, Wolf Benedict, Ference Brian, Deanfield John, Landmesser Ulf, Eils Roland
Abstract excerpt
BACKGROUND: In primary cardiovascular disease prevention, early identification of high-risk individuals is crucial. Genetic information allows for the stratification of genetic predispositions and lifetime risk of cardiovascular disease. However, towards clinical application, the added value over clinical predictors later in life is crucial. Currently, this genotype-phenotype relationship and implications for...
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