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Article

Exploring the role of ethylammonium bromide as an ionic liquid in amyloid aggregation modulation for ALS-linked hSOD1 E49K mutant.

Bioorganic chemistry - 1 Aug 2025

Keivan Behjou Nasrin, Seyedalipour Bagher, Hosseini Faradonbeh Seyed Mahdi, Hosseinkhani Saman, Chaeichi Mohammad Javad

Abstract excerpt

Ionic liquids (ILs) offer a diverse and tunable approach to inhibiting amyloid protein formation, providing new strategies to develop anti-amyloidogenic agents for amyloid-based diseases, as explored in protein-IL research. This study explores the formation of amyloid aggregates of the E49K mutant under amyloidogenic conditions and evaluates the inhibitory potential of ethylammonium bromide (EABr) as an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40664152
DOI: 10.1016/j.bioorg.2025.108740

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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