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Article

Inhibitory effect of silymarin on amyloid formation in ALS-associated hSOD1 P66R mutant.

International journal of biological macromolecules - 1 Jul 2026

Hosseinpoor Zahra, Seyedalipour Bagher, Behjou Nasrin Keivan, Hosseinkhani Saman, Baziyar Payam

Abstract excerpt

The aberrant aggregation of human superoxide dismutase 1 (hSOD1) into β-sheet-rich amyloid fibrils is a crucial process in the pathogenesis of amyotrophic lateral sclerosis (ALS), enhancing motor neuron degeneration and disease progression. The P66R mutation in SOD1 destabilizes local structure and promotes β-sheet-driven fibrillation, which makes it a suitable model for exploring approaches for reducing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42250707
DOI: 10.1016/j.ijbiomac.2026.152922

Genes

SOD1

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