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Article

Insight Into Factors Influencing the Aggregation Process in Wild-Type and P66R Mutant SOD1: Computational and Spectroscopic Approaches.

Proteins - 1 Apr 2025

Farrokhzad Roghayeh, Seyedalipour Bagher, Baziyar Payam, Hosseinkhani Saman

Abstract excerpt

Disturbances in metal ion homeostasis associated with amyotrophic lateral sclerosis (ALS) have been described for several years, but the exact mechanism of involvement is not well understood. To elucidate the role of metalation in superoxide dismutase (SOD1) misfolding and aggregation, we comprehensively characterized the structural features (apo/holo forms) of WT-SOD1 and P66R mutant in loop IV. Using...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrophobic and Hydrophilic Interactions

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Share to Spectroscopy, Fourier Transform Infrared

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Identifiers

PMID: 39643934
DOI: 10.1002/prot.26765

Genes

SOD1

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