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Modulating ALS-Related Amyloidogenic TDP-43307-319 Oligomeric Aggregates with Computationally Derived Therapeutic Molecules.

Biochemistry - 4 Feb 2020

Laos Veronica, Bishop Dezmond, Lang Christian A, Marsh Nicole M, Cantrell Kristi Lazar, Buratto Steven K, Singh Ambuj K, Bowers Michael T

Abstract excerpt

TDP-43 aggregates are a salient feature of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and a variety of other neurodegenerative diseases, including Alzheimer's disease (AD). With an anticipated growth in the most susceptible demographic, projections predict neurodegenerative diseases will potentially affect 15 million people in the United States by 2050. Currently, there are no cures for...

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PMID: 31846303
DOI: 10.1021/acs.biochem.9b00905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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