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Article

Uncovering the protein aggregation process through effect of G41D mutant SOD1 charge variation in ALS disease.

Scientific reports - 27 Aug 2025

Waheed Zainab Abdullah, Colagar Abasalt Hosseinzadeh, Seyedalipour Bagher, Baziyar Payam

Abstract excerpt

Neurodegenerative disorders are a group of hereditary and sporadic conditions that are characterized by progressive nervous system dysfunctions. Mutations in the gene encoding human superoxide dismutase 1 (hSOD1) were among the first to be proposed in line with the protein aggregation theory for ALS disease. This study aimed to characterize the (G41D) mutation/charge effects on the biochemical and biophysical...

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Identifiers

PMID: 40866479
DOI: 10.1038/s41598-025-16910-9
PMCID: PMC12391540

Genes

SOD1

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