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Modulation of amyloid formation in the hSOD1 R115G mutant by an ionic liquid ([BMIM][SCN]).

Biochemical and biophysical research communications - 31 Dec 2025

Rezaei Kimiya, Seyedalipour Bagher, Behjou Nasrin Keivan, Faradonbeh Seyed Mahdi Hosseini, Hosseinkhani Saman

Abstract excerpt

Protein aggregation is crucial to the molecular pathogenesis of amyotrophic lateral sclerosis (ALS), particularly in cases involving superoxide dismutase 1 (hSOD1) mutants. There is increasing focus on the development of small-molecule modulators that can disrupt aggregation pathways. Recently, ionic liquids (ILs) have been recognized as effective modulators of protein aggregation due to their tunable...

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PMID: 41275793
DOI: 10.1016/j.bbrc.2025.153017

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