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Article

Inhibitory effect of epigallocatechin-3-gallate as a potent anti-amyloidogenic agent against the G138E mutant of SOD1.

Scientific reports - 4 Apr 2026

Sheikhpour Zahra, Seyedalipour Bagher, Ataei Farangis, Baziyar Payam, Akhlaghi Mona, Hosseinkhani Saman

Abstract excerpt

SOD1 misfolding leads to protein aggregation, which is a common feature of neurodegenerative diseases such as ALS. The effect of epigallocatechin gallate (EGCG) as a potent anti-amyloidogenic polyphenol on the G138E-SOD1 mutant was investigated using computational/experimental approaches. MD simulation results (RMSD, RMSF, Rg, SASA, PCA, and FEL) showed that EGCG binding stabilizes the mutant in a structure...

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Identifiers

PMID: 41935163
DOI: 10.1038/s41598-026-42742-2
PMCID: PMC13212584

Genes

SOD1

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