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Article

Somatic mutations in IRE1α regulate keratinocyte migration and survival by differentially activating Rho GTPases.

Journal of cell science - 15 Aug 2025

Mogre Saie, Robinson Lily, Sethia Komal, Rimal Bipin, Son Jeongin, Pacifico Christian, Santy Lorraine, Patterson Andrew, Glick Adam B

Abstract excerpt

IRE1α is an endoplasmic reticulum (ER) transmembrane protein with cytoplasmic kinase and endoribonuclease (RNase) domains. Under ER stress, IRE1α can splice Xbp1 mRNA enabling translation of this unfolded protein response transcription factor or mediate sequence-specific degradation of mRNAs through regulated IRE1α-dependent decay (RIDD). Somatic mutations in IRE1α occur in many different human cancers including...

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PMID: 40654133
DOI: 10.1242/jcs.263790
PMCID: PMC12517464

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